Royal Air Force Typhoon fighter aircraft have operated alongside French aircraft in a joint strike against an underground arms cache in Syria used by the IS group, per a report from the British defence ministry.
The location, pinpointed through intelligence, was thought to be containing munitions and bombs, the statement said, and was situated in mountainous terrain just above Palmyra in central Syria.
"Our aircraft employed laser-guided Paveway IV weapons to target a several approach shafts down to the facility... initial indications indicate the target was engaged successfully," the MoD said.
There was no evidence of any civilian impact in the operation on Saturday evening and all the aircraft returned safely, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - also known as ISIS - imposed militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This operation shows the UK's leading role, and determination to work closely with allied nations, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the area," the British Defence Secretary the minister said.
British military aircraft have conducted overwatch operations over Syria to "prevent any attempted resurgence" of IS after its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank the personnel of our armed forces who took part in this mission for their professionalism and their courage," the Defence Secretary commented. "They were among a great many British personnel deployed over the holidays. This mission, to remove militants who endanger our safety, demonstrates how UK forces are ready to step up, continuously, keeping Britain secure within its borders and strong abroad."
During December, the American forces executed what it described as a "massive strike" targeting IS targets in the country, after an attack resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The United Nations says Islamic State still maintains roughly 5-7 thousand combatants in Iraq and Syria.